Brain Wave Signature Predicts Seizure Surgery Success and Objective EEG

For about one in three people with epilepsy, medications don’t control seizures, making surgery a key option. A new study from Nanjing Brain Hospital, published in Annals of Clinical and Translational Neurology, proposes an objective EEG-linked marker of success for stereoencephalography-guided radiofrequency thermocoagulation (SEEG-RFTC). The approach uses depth electrodes under robotic navigation to record seizure onset and deliver radiofrequency energy, creating thermal lesions about seven millimeters wide with heating up to 80°C. The researchers focused on seizure-onset patterns and highlight low-voltage fast activity (LVFA). In 25 patients treated between 2022 and 2024 with at least 12 months follow-up (mean 31.6 months), 12 of 13 patients whose seizures began with an LVFA-containing pattern showed favorable outcomes.