Everything to Know About Amyloidosis

Amyloidosis is a condition in which abnormal proteins build up in organs such as the heart or kidneys, disrupting function. The article explains that the disease is a protein misfolding disorder and can be systemic—affecting multiple organs—or localized to one area. It says symptoms vary depending on where the deposits form, and may include fatigue, dizziness or fainting when standing, numbness and tingling in hands or feet, urine changes, leg and ankle swelling, digestive problems, skin alterations, an enlarged tongue, muscle enlargement, irregular heartbeat, and shortness of breath. Causes include secondary origins linked to other conditions, inherited gene mutations, or cases associated with long-term dialysis, though sometimes the cause is unknown. Treatment focuses on managing symptoms and slowing progression, as there is no cure.