Exploiting classical virulence factor: staphylococcal protein a in immunotherapy and immunodiagnosis - Journal of Proteins and Proteomics

The Journal of Proteins and Proteomics article explores how the staphylococcal virulence factor staphylococcal protein A can be used in immunotherapy and immunodiagnosis, grounding the discussion in existing datasets and prior research. The paper’s provided reference section emphasizes earlier work on staphylococcal biofilms, immune evasion mechanisms linked to protein A, and research on protein A release from Staphylococcus aureus. It also cites studies addressing the roles of antibody Fc interactions, surface-anchoring of bacterial proteins via sortase enzymes, and human immunity patterns involving IgG3 effector functions. Additional references focus on broad microbiology and immunology frameworks, including methods used to study clinical laboratory detection concepts. The document indicates that supporting datasets are available from the corresponding author upon reasonable request. Overall, the scholarly framing ties molecular and immunological mechanisms to potential translational uses in diagnosing and treating infections involving S. aureus protein A.