Learning to Live With hATTR Amyloidosis

hATTR amyloidosis, a form of hereditary transthyretin (hATTR) disease, causes protein buildup that can affect the heart and other organs. The article lists heart-related symptoms consistent with heart failure, including fatigue, shortness of breath, and leg swelling, along with irregular heartbeats such as atrial fibrillation, pacemaker needs, and aortic stenosis. Non-cardiac issues can include neuropathy pain, numbness and tingling, bilateral carpal tunnel syndrome, back pain with spinal stenosis, and histories of hip or knee replacement. Autonomic dysfunction can lead to constipation, digestive issues, kidney problems, sexual function issues, and vision changes. It notes studies suggest death often occurs 5 to 10 years after diagnosis, but treatment may extend lifespan. FDA-approved therapies since 2019 include Vyndamax (tafamidis), Attruby (acoramidis), and Amvuttra (vutrisiran), and trials may offer additional options.