Bills vs. Steelers prediction: 'Thursday Night Football' NFL preseason picks, best bets

Buffalo is favored by 2.5 points as the Bills host the Steelers in their final preseason game before the regular season. The key detail is that neither team appears likely to play its usual starting quarterback. For Pittsburgh, Drew Allar and Will Howard will split snaps behind center, while Kyle Allen and Shane Buechele run most of Buffalo’s offense. Steelers quarterback play will be tested after a rough previous outing vs. the Jets, when Pittsburgh lost 17-0 and Howard threw two interceptions. The Bills also come in hotter, with Allen going 24-for-28 for 236 yards across two preseason games. The betting pick presented is Bills -2.5 (-114, FanDuel).