College football odds, predictions, picks, Week 2 betting guide - CBS Sports

CBS Sports highlights its Week 2 college football betting guide, citing SportsLine’s model as the source for picks and odds. The most prominent matchups include Ohio State vs. Texas, with Texas ranked No. 4 as 1.5-point home favorites over the top-ranked Buckeyes, and Michigan vs. Oklahoma at The Big House, where the Sooners are 5-point road favorites after Michigan’s controversial Week 1 win over Western Michigan. Other schedule highlights list in-state games and trophy matchups, including LSU vs. Louisiana Tech (+35.5), Penn State vs. Temple (+24.5), and Iowa vs. Iowa State (+14). SportsLine says it simulates each FBS game 10,000 times and has produced a 33-20 run on top-rated CFB money-line picks since 2024, upgraded for 2026. Two model recommendations stand out: Kentucky (+10, 48.5) to cover Alabama at a 3:30 p.m. ET kickoff, and Iowa State (+14, 41.5) to cover at Iowa at 7:30 p.m. ET.