College football score predictions: Best bets today, picks for Week 1 - CBS Sports

SportsLine’s model has released its 2026 Week 1 college football score predictions across the full slate, starting Saturday and continuing through Labor Day Monday. Among the marquee matchups, LSU is listed as a 10-point favorite over Clemson, while Ole Miss is a 6.5-point favorite against Louisville in the week’s only ranked-on-ranked pairing. The article notes the model simulates every FBS game 10,000 times and has been updated for 2026 to better incorporate the transfer portal, citing a 32-19 run on top CFB money-line picks since 2024. One highlighted prediction has Penn State beating Marshall 37-12 in Matt Campbell’s debut, with Penn State also projected as -23.5 and the total at 52.5.