DraftKings Main Slate Build Week 5 NFL 2026: Let Chaos Reign

Week 5 of the 2026 NFL season features an 11-team DraftKings main slate, with the Lions at Cardinals the clear focal point. Detroit is a road favorite, plus 5.5 for Arizona, and the game carries a 54.5 over/under—an 8.0-point spread over the next highest total games. The piece emphasizes tailoring lineups by contest type: larger-field tournaments need more leverage, small-field contests lean closer to “chalk,” and cash games essentially reward favorites with some differentiation. Projected ownership spotlights Jahmyr Gibbs (45%), D’Andre Swift (30.8%), and Trey McBride (20–30%). Injury watch includes Stefon Diggs, Ashton Jeanty, and Breece Hall.