Eagles Week 5 fantasy football injury report vs. Jaguars: DeVonta Smith injury is bad news for floundering offense

The Philadelphia Eagles enter Week 5 of the 2026 NFL season dealing with a heavy injury situation ahead of their matchup against the Jacksonville Jaguars in London. Kickoff is set for 9:30 AM ET, and the team reportedly has 15 players listed on its injury report, with eight out or questionable. Complicating matters further, the Eagles are adjusting after Lane Johnson’s abrupt retirement and after Howie Roseman traded Cam Jurgens to the Baltimore Ravens for two draft picks. From a fantasy perspective, the piece suggests it’s difficult to rely on Philadelphia’s backfield: Saquon Barkley is out, and Tank Bigsby is on injured reserve after surgery. Will Shipley’s role looks uncertain, and backups include Dameon Pierce and Carson Steele.