NFL odds, betting, storylines: 2 underdogs to back in Week 6

Week 6 betting coverage looks to two underdogs, after a Week 5 stumble ended a run of seven correct underdog picks in eight tries from Weeks 2-4. The first play targets Texans vs. Jaguars at London, where Houston is listed as +2.5. The Texans got their first win of the 2026 season in Week 5, covering for the first time after routing Tennessee 26-3. Jacksonville comes in having won 12 of its last 13 regular-season games, covering 11 of 13. Despite Houston’s modest recent edge in series history, the column argues oddsmakers are overvaluing the Jaguars after their London win.