Patriots vs. Bills odds, picks, prediction, spread: NFL Week 4 start time, betting preview, best bets - CBS Sports

Kickoff is set for 1 p.m. ET as the New England Patriots visit New Highmark Stadium for an AFC East matchup with the Buffalo Bills in NFL Week 4. Buffalo is a 6.5-point favorite at DraftKings Sportsbook, with an Over/Under of 48.5 total points. The preview credits SportsLine’s Projection Model and NFL experts, saying the model has simulated every NFL game 10,000 times and is ahead on top-rated picks. On the field, the Bills are in their third straight game at New Highmark and have scored 65 points over their first two contests there. Buffalo is averaging 786 passing yards by Josh Allen with five TDs and two interceptions in the season context cited, while James Cook III is third in the NFL in rushing with 346. New England’s defense ranks fifth, allowing 17 points per game, but the Patriots are tied for the league lead with eight giveaways.