Notre Dame vs Purdue Prediction: Odds, expert picks, team and player news, betting trends, and stats

Notre Dame is a heavy favorite against Purdue in a game set for NBC and Peacock on Saturday, September 26, 2026, at 2:00 PM Eastern at Ross-Ade Stadium in West Lafayette, Indiana. After last year’s 56-30 Notre Dame win—when Purdue covered late—the narrative has shifted toward the Irish as national title contenders and a top defense. Through three games, Notre Dame has allowed just 295 total yards and 10 points over its last two outings. The Fighting Irish open 2026 with wins over Wisconsin (41-13), Rice (52-0) and Michigan State (27-10). DraftKings lists Notre Dame at -27.5 and the total at 58.5.