Chargers vs. Chiefs Prediction, Odds, Spread, Injuries, Trends for NFL Week 6

The Kansas City Chiefs return from their bye aiming to stay perfect in Week 6 against the winless Los Angeles Chargers at Arrowhead Stadium on Sunday, Oct. 18 (4:25 p.m. EST, CBS). Kansas City is a heavy favorite, listed at -8.5 in the spread, with the moneyline at -440. The Chargers (0-5) are priced at +340 and have failed to cover the spread in all five games. Quarterback Justin Herbert has regressed, throwing five touchdowns and seven interceptions while completing 59.4%. Injuries cloud both sides: L.A. has multiple questionable starters and several IR designations, while Kansas City’s Rashee Rice is questionable and Tyquan Thornton is out. The key matchup centers on Kenneth Walker III’s impact role.