Patriots vs. Seahawks prediction, odds, pick for 2026 NFL season opener

The 2026 NFL season kicks off Wednesday night with a Super Bowl LX rematch: the New England Patriots at the Seattle Seahawks. The Patriots finished 14-3 in 2025, won the AFC East for the first time since 2019, and beat the Los Angeles Chargers in the Wild Card before defeating Houston and Denver. New England then lost 29-13 to Seattle in the Super Bowl. Offseason changes include the departures of Srefon Diggs and Kayshon Boutte and additions such as A.J. Brown, Alijah Vera-Tucker, and Walter Rouse, plus a contract extension for Christian Gonzalez. Seattle went 14-2 in 2025, beat the 49ers and Rams in the playoffs, won the Super Bowl, and added Jadarian Price along with Dante Fowler, Rodney Thomas, and Avery Smith. DraftKings lists Patriots +3 (-102), Seahawks -3 (-118), with an over/under of 44.5.