Integrated Healthcare Pathway for People Who Use Drugs Evaluated in

A retrospective observational cohort study in Tayside, Scotland evaluated a nurse-led, low-threshold integrated healthcare pathway for people who use drugs. Implemented across harm reduction settings with three visits every six months, the program aimed to provide ongoing contact and referrals. Between August 17, 2021, and August 31, 2024, 150 people received care; polydrug use was reported by 142 participants (95%), with a mean of 7 substances. Re-engagement was recorded for 69% at the second visit and 55% at the third. Compared with conventional support services, the pathway showed higher adjusted odds of non-fatal overdose (aOR 2.50) but no statistically significant difference in fatal overdose (aOR 1.82). Researchers say the lack of detectable excess mortality may reflect better monitoring, but limitations include observational design and attrition.