Medicine doctor explains what can happen after stopping GLP-1 drugs | Fingerlakes1.com

A University of Rochester Medicine physician says stopping GLP-1 drugs often leads to increased hunger and some weight regain, urging patients to coordinate any change with a care team. Dr. Susan Gasparino, medical director at UR Medicine’s Center for Community Health and Prevention, described obesity as a chronic, relapsing condition where medication is commonly recommended as long-term therapy. She said GLP-1s—including Wegovy, Zepbound and Ozempic—help suppress appetite, but after stopping the body may produce fewer fullness-related hormones and more hunger-triggering hormones. Gasparino noted clinical trials show many patients regain a significant portion of lost weight. Reasons for stopping can include side effects, insurance changes, or limited results. She recommends planning with clinicians, maintaining nutrition, exercise, sleep and stress habits, and ensuring appropriate follow-up.